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We're reviewing our procedure for the provision of blood products before completion of pretransfusion/compatibility testing. Our medical staff has also asked for an educational tool that can be used house-wide. I'm very curious of the generally accepted practice standards of the BBT community. One major focus is on how everyone handles a situation where an antibody screen is positive (or a patient has a history of clinically significant antibodies/special transfusion requirements) and transfusion is needed prior to the completion of antibody ID and/or acquisition of appropriate products. Does your medical director/on-call pathologist get involved? Does the supervisor/manager/Lead/Senior tech get involved? Are there instructions for the selection of 'best matched' products? Are there special forms to be signed? Is this handled under the same policy/documentation as when a blood product is emergency released due to no type and screen specimen? Is anyone willing to share some information or even their policy/process/procedure documents? Does anyone have any good reference articles about this topic or even an educational tool they used at their institution and would be willing to share? Thanks in advance and happy Holidays!! Literature that was able to be retrieved from PubMed: Goodell PP, Uhl L, Mohammed M, Powers AA. Risk of hemolytic transfusion reactions following emergency-release RBC transfusion. Am J Clin Pathol 2010;134:202-6. Johnson V, Langeberg A, Ahmad M, Sandler SG. Emergency transfusion of incompatible red blood cells [letter]. Arch Pathol Lab Med 2007;131:1514-1515.Mulay SB, Jaben EA, Johnson P, Badjie K, Stubbs JR. Risks and adverse outcomes associated with emergency-release red blood cell transfusion. Transfusion 2013;53:1416-20.Ong MG, Ezidiegwu C, Beadling W, Rosales LG. Re: Emergency transfusion of incompatible red blood cells [letter]. Arch Pathol Lab Med 2008;132:1386.Saverimuttu J, Greenfield T, Rotenko I, Crozier J, Jalaludin B, Harvey M. Implications for urgent transfusion of uncrossmatched blood in the emergency department: The prevalence of clinically significant red cell antibodies within different patient groups. Emerg Med (Fremantle) 2003;15(3);239-43.