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Showing results for tags 'autocontrol'.
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Does anyone run an autocontrol with the antibody screen if the patient has a history of clinically significant antibodies? We do not normally run an autocontrol with our antibody screens (gel). We run them when we do panel work. I recently ran an autocontrol anticipating a positive screen as the patient already had 3 antibodies, the screen reacted last month, and he had been transfused recently. The screen was negative, the autocontrol was positive, and the eluate was negative. I did go beyond our policy since the screen was negative, but I felt better about issuing the blood, and talked to the supervisor about it. We'd both like to know what the policy is at other places.
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For those of you treating cells with DTT for patients taking daratumumab/darzalex: Have you come across a positive autocontrol, with treated and untreated cells? Currently, patient on DARA: initial screen-panagglutinin, auto-positive. Testing with treated cells: screen-negative, auto-positive. QC-valid (testing Kpos and Epos cell) antigen typing for K-neg, E-pos I have been unable to find any research with this information. We are currently in the process of validating DTT treatment. Any advice would be welcomed. Thank you