My opinion is that for the analyzer your using it is definitely over calibration. First, CAP and CLIA definately DO NOT require this. Second, it is incredibly wasteful to perform all those multipoint calibrations and QC to turn out a patient result. I find it hard to believe your profiting on this testing unless your volume is very high. Third, it seems to me that calibrating that often could potentially hide imprecision in your analyzer. In other words, if there were something wrong with the analyzer that would cause the results to drift, you would not catch it since you’re constantly ajusting your curve. Fourth, and perhaps most importantly, calibration is not without its dangers. What if there was a random inaccuracy in one of the calibration tests; enough to cause a shift, but not a failure. It seems to me that you could actually make a good assay less accurate by calibrating it.