Hi. We encountered an interesting case tonight. A male patient with no history of transfusion (also said he's never been transfused) typed beautifully A Pos. His screen, however, was positive 3+ for cells 1 and 2 and then D pos panel cells ranged from 1+ to 3+. The D negative panel was negative and antibody ID panel was positive for all D pos cells.
We then looked as his med list. He's on Bicalutamide, but there's no mention of BB interference in any literature I've Googled. He has a hx of prostate cancer and family hx of malignant neoplasms.
Tube results were negative across the board (I used both LISS and no LISS to see if any difference). They were text book, beautifully negative at that for all phases.
DAT negative.
What could be an explanation of this??? Is there any cases of solid phase D reacting due to meds? Meds are the only conclusion we've come to so far. Any thoughts???