The Circular of Information, revised Dec 2009, states: " Transfusion of CMV-negative blood is indicated in CMV-seronegative recipients who are at risk for severe CMV infections. These at-risk groups include pregnant women and their fetuses, low birthweight infants, hematopoietic progenitor cell transpland recipients, solid-organ transplant recipients, severely immunosuppressed recipients, and HIV-infected patients. Leukocyte-reduced components may be an alternative to CMV-seronegative transfusion in some clinical conditions." Unfortunately, it DOES NOT say what the 'some clinical conditions' are..... In addition to the cases stated above, we continue to give CMV-negative product to those who have tested CMV-negative. Their CMV status is entered in to our computer system so there is no question when they come in for transfusion.