Brenda, here is some more info on the f antigen that I found quite helpful. The f antigen, an example of a compound antigen, is expressed on RBCs having c (RH4) and e (RH5) antigens in the same haplotype (in cis), for example, R1r (DCe/dce), R0R0 [Dee/Dee], etc. The antigen is not expressed when c and e occur on separate haplotypes (in trans), e.g., R1R2 (DCe/DcE). However, RBCs of some people with the De- phenotype express f. Anti-f is frequently a component of sera containing anti-c or anti-e. Anti-f is useful in distinguishing DCE/dce from DCe/DcE. Apparent anti-f in Blacks may be anti-hr's (see RH19). Anti-f frequently fade in vitro and in vivo.