Hope some expert can shed some light on this. Patient history O Pos, done on 3 seperate samples in 2009. Patient received 1 unit rbcs in 2009. Today, patient is O Negative, done on 3 seperate samples, one of which was a witnessed draw by myself. Patient denies Bone marrow or stem cell transplant - diagnosis is CML. My best guess, based on Google, is a rare phenomenon seen in CML patients due to a mutation? Of course, she was given O Neg rbcs.