zafer

I will be there 

I am enormously honoured to announce that I am going to be awarded the Gold Medal of the British Blood Transfusion Society at their Annual Scientific Meeting in Brighton this year.  It is awarded to an individual for their exceptional and long standing services to the Society and to the practice of blood transfusion in the UK.  Sorry if this sounds egocentric, but I am very excited.

I just saw this seminar being offered by Bio-Rad with our own, infamous, Malcolm Needs as the presenter. I registered and thought I'd pass the word to all of us here. Here is the link:https://info.bio-rad.com/ww-IHD-transfusion-w-registration-lp2.html?elq_mid=48765&elq_cid=10201434&elqCampaignId=30837&utm_campaign=30837&utm_source=eloquaEmail&utm_medium=email&utm_content=Email 13ER EM-R-CM-385201-FY21-TCHS-AWEN_BR-JRNL-TRF News 19 Nov&elqTrackId=6ecbbea5f2bb46849981687404578a8e&elq=7c5f74470efa434dbd4351e512f7ae7a&elqaid=48765&elqat=1&elqCampaignId=30837

I will be there 

As someone that works in a small blood collection facility, my first thought was how did this get through testing. Then I realized the problem is probably related to the antigens, not an antibody. First thing we check is DAT of the unit, which is negative. Then we would test against a couple of random samples from each compatible blood type, which you did. Then I would do a more elaborate ABO, which if there was a problem should have (in theory) been caught during testing. Then I thought about your reactions, 4+ tube, 2+ Gel, that's backwards from "normal" reactivity. Here we see a difference in reactions of at least one, usually two levels higher in Gel than tube. Unless whatever is happening is more IgM than IgG....... Then I think, do we all have Nabs that would react to some super low-incidence antigen? That was literally my thought process in 2 minutes, with no logical brakes. LOL. I'm not knowledgeable enough with this off the top of my head, so now it's time to read. Please post what the supplier says.  

I think it more likely that the donor is expressing an antigen, such as T, Tn, Tk, Cad, etc, possibly as the result of a subclinical infection if this has not been seen before with his/her blood (which would rule out Cad).  Have you tried testing it with a lectin panel?

I agree. We need more information, such as age, underlying pathology, etc.