I work in a hospital that does differential adsorptions for warm autos. We identify and/or rule out alloantibodies and crossmatch using the adsorbed plasma. My question is: even though the crossmatches may "appear" compatible in vitro, they are not really compatible in vivo. All we have done is to make sure there are no alloantibodies present. The patient's autoantibody will react to the transfused cells, causing further hemolysis. The units go out on these patients as compatible, and the doctors do not have to sign for them, even though they are not truly compatible. I am wondering what the policy is in other hospitals regarding these adorbed-plasma-crossmatched units being called "compatible" vs. "incompatible" and the doctors having to sign for them. I'd appreciate hearing everyone's idea on this. Thanks.