I took it to mean that it must be issued by expiration (per the FDA regs, I think, but don't quote me). However, the new AABB 28th Standards has reworded Administration of Blood and Blood Components 5.26.3 #5 "The unit has not expired". It does not say that it must be completed before expiration. Bottom line, if you issue close to expiration, make sure that transfusionist can begin transfusion before expiration. R1R2