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April 2024 Challenge

Malcolm Needs

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Posts posted by Malcolm Needs

    Antibody ID

    in Transfusion Services

    Posted

    13 hours ago, Yanxia said:

    May you kindly give us more details about it?  Is it about the ionic strength? Thank you.

    I confess that I am no expert on the chemistry of this, but, as I understand it from the late Prof. Patrick Mollison's book, it is purely to do with differences in the equilibrium constants of weak and strong antibodies.

    Antibody ID

    in Transfusion Services

    Posted

    In the Reference Laboratory I worked in (in the UK, NHSBT-Tooting Centre in London), we would freeze any useful samples from both patients and donors (although the latter were quite rare), but we also belonged to a scheme named SCARF (Serum, Cells And Rare Fluids).  I must confess that, having retired in late 2016, I'm not certain that SCARF is still going, or, come to that, how much it costs to join.

    One thing that I would caution against, and that is diluting a "strong" antibody to make a "weak" antibody (although this is far more important when trying to make a "weak antibody" to use as a control (for example, for an IAT), as a "strong" antibody has a completely different equilibrium constant (although this may not be too important if you just use them for teaching).

    Imelda Bromilow.

    in All other topics

    Posted

    1 hour ago, noelrbrown said:

    Thanks for letting us know, I worked with Imelda on a couple of projects when she was at Liverpool BTS.  I always enjoyed her humour and approach to life.

     

    Noel

    Yes.  She was one of a kind!

    Anti-Sciana 3

    in Immunohematology Reference Laboratories

    Posted

    Vis-a vis Sc:-3 blood, I remember when I was working as a VERY junior member of staff in the IBGRL Red Cell Reference Laboratory of Dr Carolyn Giles and Joyce Poole, we did a family study following the relatives of an Sc:-3 female in a small village in Papua New Guinea (PNG), and we found six others.  This was at least 40 years ago now, but it may be worthwhile contacting the PNG Blood Service to see if any of them are still donors, or, indeed, if they have found any other such donors.

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