In my defefence, I was not looking at the antibody screen as the anti-c/E were already confirmed. I was looking only at the ABO grouping as O in reverse group. We recently had a haematology proficiency here where a CLL patient had p.falcip. Nobody spotted the malaria because they were too busy looking at the high WCC. Maybe the ABO dicrepency has nothing to do with the Anti-E/c. The only other reason I could think of other than the ones mentioned in other replys was an anti-A1 etc. As the patient is A1 then the suspician falls back on the anti-E and c as the most probable culprits.