I had something similiar to this happen to me. I work at a reference lab, which does not get any patient information besides name, age and sex. So, it is pretty difficult to determine what problem you could be facing with a patient. Our machine basically runs the show, you put the samples on, it does type and screen, and the panels. At the end of the day, i see a sample that is Rh positive with an Anti-D antibody. Ever since this, I have been researching to try to figure out how this could be since there was no error in handling. We use the capture plates, not gels, but I did run a titer on a gel and it was 1:2. All reactions for the panel were 4+ and clearly could not be any other antibody except D. I repeated the type on tubes, and it had a 2+ reaction for D4, screening cells were 2+ and 3+ so, all the reactions were quite strong. We don't have the ability to do elutions or anything fancy like that, but I was just curious of what this could be. I too, thought it may be an auto Anti-D but I don't know for sure.