Howdy Blood Bankers! I am wondering what everyone is doing regarding the CLIA regulation change that happened last Sept, saying that IgG gel crossmatches do not detect IgM antibodies (i.e. anti-A or anti- and that you must also perform an Immediate spin XM, electronic XM in addition to performing the gel XM. This has just come up in our laboratory, and before we implement a change in how we perform our crossmatches for our patients with antibodies:cries:, I would like to see if there is any alternatives out there. We are currently inspected by CAP and AABB, but I'm sure the CLIA regulations are somewhere in there. I personally performed a "mini" validation of the IgG gel cards, and yes, they do detect ABO incompatibility, but I've been told that that may not be relevant. Any ideas???