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April 2024 Challenge

Yanxia

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Everything posted by Yanxia

  1. Yanxia
    But with the use of monoclonal antibodies, I am not sure whether the reaction is so typical as book says. And some different A subgroup defined by serological method may have same genetic background, so I think the most important things is how to transfuse not the naming.
  2. Yanxia
    If the A antigen reaction only be seen in adsorption and elution test, I think it is Ael.
  3. Yanxia
    I think at first step, test this patient's cells use anti-AB, if the reaction is stronger than with anti-A, then it is Ax type. 2nd, if the anti-AB reaction strength is the same with anti-A, then do adsorption and elution test, to see if there are A antigens on the cells. 3nd, test the cells use anti-H, to see if there is some kind of parabombay or more rarely bombay type. As to the reverse group, I think we should add a tube of O cells as negtive control, to make sure the reaction when we add more serum or prolong the incubation time or incubation them at 4 degree C is actually anti-A. This is my personally opinions
  4. Yanxia
    I will not use enhancement in the immediate spin crossmatch. 1.If the weak reverse antibodies are caused by sub group, I will select the compatible ABO group components for the patient. Such as AxB we will give the patient B washed red cells and AB plasma and platelets. 2.If the weak reverse antibodies are caused by age or immunosuppression, we will treat it as normal ABO group accoding to the forward grouping result. Since we use the IS crossmatch is safe for most of patients, it means it can detect lots of clinical significant IgM antibodies, the sentivity is ok, so I will not add enhancement.
  5. Yanxia
    Maybe my understanding about this question is wrong, because of my not good English and not good professional knowledge. But I still can not stop myself from speaking out my opinion. As usual, corrections are always welcomed. If the autocontrol is pos, I will do poly then IgG and C3 DAT specifically. But there are also some pos auto, but neg DAT, then I think there are two kind of situations: 1. the method interference. 2.the auto antibodies are too weak to be tested by DAT, in this circumstance, I prefer to do an elution test.
  6. Yanxia
    I think D neg bloods may be better
  7. Yanxia
    May I ask what is PVP?
  8. Yanxia
    Sounds like a waste of resources to me
  9. Yanxia
    I am in China, I don't know the rules or regulations in the USA. I will keep tube as a backup since gel method sometimes are too sensitive and easy to be interfered by some factors, such as cold antibodies, proteins or sickle cells.
  10. Yanxia
    we don not use it either, but I think use it may be easy to watch
  11. Yanxia

    :)Happy holiday and the best wishes for you

    1. Malcolm Needs

      Malcolm Needs

      Thank you so much shily, and the same to you and your friends and family.

  12. Yanxia

    :)Happy Birthday

    祝您生日快乐

    1. Malcolm Needs

      Malcolm Needs

      Thank you very much indeed shily.  That's a lovely way to start the day!

       

      With very best wishes,

       

      Malcolm

  13. Yanxia
    what about the baby"s c antigen, is it pos or neg? I will transfuse c neg blood to the baby, since there are anti-c antibodies in his or her circulation.
  14. Yanxia
    Thanks, Anna. Your explaination is very good. It was because my poor English.
  15. Yanxia
    There is a question confused me, why it is dangerous of giving double doses of anti-D Prophylax. I know it is a waste Do you mean there is a risk of infection? Thanks
  16. Yanxia
    But this can not explain why the same specimen got different result in two labs
  17. Yanxia
    I heard the news all about it yesterday, really sad.
  18. Yanxia
    I had met specimen showed different reaction in our lab and reference lab, we guess it was because drugs. The drugs concentration in the patient's blood will reduce along with time
  19. Yanxia
    I am sorry to hear the accident
  20. Yanxia
    I think we should take into consideration immune-tolerance and blood group substance's neutralization here
  21. Yanxia
    I know we want to get the high concentration of antibodies, it is the reason we use enhancement in our testing. My meaning is there is part of antibodies which will not be the culprit of HDFN, or weaker in the newborn's blood circulation will not cause severe HDFN. Use cord bloods will cause confusion. Because the IgG antibodies are transported by the placenta, will be concentrated in the cord bloods.
  22. Yanxia
    I think there are two reasons we don't use cord specimen 1.the Wharton jelly in it will cause rouleux agglutination of cells 2.the antibodies came from the maternal circulation will be concentrated in the cord blood, the concentration is higher than in the maternal blood and neonate's blood circulation, will cause false positive.
  23. Yanxia
    I wonder whether the transfusion of a patient with autoantibodies is some kind of in vivo crossmatch.
  24. Yanxia
    I had discussed this with a renal doctor, he said it is maybe because some renal disease is caused by immunologic disorder.
  25. Yanxia
    I had to admit that we had not do good enough to share with you. Just for reference. We will document the time. We will document the time, the symptoms We call them if we have not receive report of the patient's conditions I am from China
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