Well, this discussion has given this old-fashioned Blood Banker something to think about. Interestingly, our donor center reference lab has stopped automatically supplying phenotypically-matched RBCs if there are no alloantibodies detected under the WARM. If the patient later develops an allo, then pheno-matched RBCs are provided. We had a slightly different situation occur in our lab last week. Patient had a history of WARM due to Evans Syndrome (autoimmune). This time however, only the DAT was positive. The Gel screen and IgG crossmatch were negative. The eluate was reactive with all cells. The sample was sent to the reference lab and they came back with the same results. They only recommended what we had already done. My question is: if the WARM is not spilling over to the plasma, would it be safe to issue crossmatch (in our case, Gel)-compatible RBCs for transfusion? I think I am getting too conservative in my old age.