We made our own QC for Provue and had very minimal problems. I have continued to made my own QC for Vision with no problems as long as I am picky about the quality of plasma I pool and use. Can't have any hemolysis or lipemia. I do have the ability to edit QC results on the Vision and this is helpful of course. I know our rep and Ortho in general were very very pushy about buying their QC, saying it wouldn't work and "nobody does that". I beg to differ since about half of my training class DID in fact make their own. It is a huge savings to make your own for sure!