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Just a question - along with mrmic - What is the average daily temperature in your lab? If this antibody is, at least partially, a "Cold" and you have a LOT of reactions like this, as you stated, it just may be too cold in your lab. Try a strict Prewarm test, as suggested by Malcom and if that helps, consider reducing the amount of Room Temp exposure your average specimen encounters and see if you can cut the reactions down. We have almost no RT exposure in our testing anymore (Immucor ECHO) but we used to have more extraneous reaction problems in the winter when our lab grew colder (think blue fingers!). Just a suggestion. Does anyone think this (second panel) may be an anti-P? It is not showing the whole pattern, but I have seen several that didn't.