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Showing content with the highest reputation on 07/02/2020 in all areas

  1. 'Liquid Plasma' is never frozen so there's no need to thaw it therefore the outdate is not changed. 'Thawed Plasma' is the 5 Day product which results from Thawing Frozen Plasma (in all it's various forms, FFP, FP24, etc.). Note: When Frozen Plasma is thawed, it is assigned a 24hr outdate. You can extend that outdate to 5 Days IF you label it 'Thawed Plasma'. e.g. Frozen FFP is thawed to Fresh Frozen Plasma (24h outdate). You can leave it that way or change it to 'Thawed Plasma' (no FFP designation) and assign a 5 Day outdate to it. Most hospitals, if they go that route, just label it 'Thawed Plasma' with a 5 Day outdate immediately after it's thawed. (One Step vs Two Steps) Note: I'm using USA FDA rules, I don't know what they do in other countries.
    1 point
  2. Can I just point out here that no one serological test, or even combination of tests will detect all weak / variant Ds . And that includes women who test D+ but actually have a partial D and may make anti-D antibodies. It is SO important to know your reagents, and know what your anti-D reagents will and will not detect
    1 point
  3. I am a worker from/in the UK, but if TRM.40780 says, "Maternal RhIG candidacy assessment must include the identification of weak-D phenotype newborns", that is exactly what it means. It doesn't say "should" instead of "must", and it doesn't say, "until you give up because you are bored, because you have never found one"! Yes, such types are rare, but they do happen, and they can cause the mother to produce an anti-D (of sorts). These antibodies are not usually particularly clinically significant in terms of further pregnancies - but the word "usually" is the important one in that sentence. The only thing I would say is, WHEN you do detect a newborn who tests as weak-D positive, don't forget to test the mother too; she may also express the same weak-D type (but, depending upon your laboratory's policy, may not have been tested as expressing this type during the pregnancy), and, if she does, she doesn't need the anti-D immunoglobulin (which, remember, is a human-derived blood product, which may contain a novel blood-borne virus type about which we know nothing - YET).
    1 point
  4. Townsend

    LISS Validation?

    Yes, you should do at least a small parallel study using the old and the new. Your director will have to decide on how many would be acceptable and define acceptability criteria prior to implementation. I would summarize and have them sign-off before placing it into use.
    1 point
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