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Looking back over, I realized that I did not specify that the patients I am talking about are the ones on chronic transfusion therapy and are transfused about every three to five weeks. They have all either had a stroke or have been identified as being at high risk for stroke.

We limit our matching to a group that is generally manageable. It has been some time ago since I looked at their recommendation, but the Sickle Cell Foundation was recommending matching further than we do. We do find that these patients develop 'warm autoantibodies' which I think are or may be a reflection of the myriad other antigens that we do not match. That being said, our practice has been successful in preventing stroke overall in a disadvantaged and usually overlooked (in my area) group of children. We have done a pretty good job of indoctrinating the patients and their families to get in touch with us when our patients go to another facility.

We always used the last tube/column in a cassette that gave a macroscopic reaction. We certainly used "too weak to titre".

bevydawn1, Here is the rule I had in 5.67. Hopefully it helps. The Data Flds From is BSP. (([f bsp ctime]-2400)/100)^X, (72-X)^Y, [f bsp exp hrs set](Y);