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We just got our first anti-CD47 out here in the sticks on a patient who went to Seattle for a clinical trial. That drug is Hu5F9-G4. No other name yet. It interfered with her reverse as well as all gel testing. We did a 30 minute saline screen and it was 4+ at 37C but negative at IAT using Immucor's anti-IgG which doesn't react with IgG4. She was antigen typed before starting treatment so we got that information and gave her K and Fya negative units (lucky she is positive for most antigens). We called them incompatible because we have not validated the Immucor anti-IgG as our test of record, the screen was 4+ at 37C and because the drug causes the patient's H&H to drop so I wasn't sure that the units would be certain to have normal survival. I didn't expect to get one of these for a few more years since we aren't in a big teaching hospital region. It would have been nice if the big center had sent her home with information that she was on this and instructions to tell the blood bank. We lucked out finding clues in Epic's Care Everywhere so we called the Seattle blood bank.

I don't think you can do much "assuming" like this in the BB, much less healthcare in general. A unexpected positive reverse cell is most likely due to something innocuous, but it could be, at the least, a sign of an ABO subgroup or whatever. In any case, you would want it all documented for the next time you see that patient. Scott

I agree with Malcolm.

Centrifuge your final eluate for 60 seconds and pipette it to a new tube. Check the old tube for fine red particulate matter adhered to the tubes sides, and if present repeat the process.

I just answered this question. My Score PASS

If the patient has been transfused or pregnant in the last 3 mos, one has to r/i r/o significant atypical antibodies every three days. This going to involve more than a screen. Scott