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Showing content with the highest reputation on 06/27/2017 in all areas

  1. I just have a hard time transfusing red cells that yield a 1-2+ positive reaction at immediate spin (can't call that compatible :o) ). That being said, we do what our pathologist requires. I agree that O mothers delivering incompatible type babies have destructive IgG ABO antibodies. We still do Lui Freeze Elutions on all neonates with positive DAT's to identify the "culprit" antibody. I'm not sure many facilities continue to do that. Thanks for the references.
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  3. Sorry Scott, but could I just jump in here? The strength of the reaction of the DAT is not a measure of anything really. It is rather like saying that, if a reaction with anti-D from a pregnant woman is weak, the foetus is not in danger, but I have seen a few cases over the years where the reaction with R1R1 and R2R2 screening cells and panel cells has been weak because the D antigen sites are swamped. The same sort of thing can happen with the DAT.
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    HLA in Transfusion & Transplantation
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