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Before I retired, we used leuko-reduced RBCs with antibody. When we began, we kept extensive records to study if the use of such RBCs caused subsequent problems; they did not. I certainly think O neg RBCs with antibody are suitable for trauma patients since much of the antibody will bleed out. Using these units increases the number of available O neg RBCs. Like David, I wouldn't use them for NICU patients. I might also avoid using them for patients with sickle cell anemia. Since these patients make so many antibodies, I wouldn't want to do anything that could potentially complicate subsequent antibody ID. We had a poster session at the 2010 AABB meeting discussing the impact.

Having also used them in an earlier life (i.e. when I used to work in a hospital laboratory some time from about 1978 to about 2000 BR [before reference]), I agree entirely with Marilyn in every respect (except, perhaps, I would include any transfusion-dependent with a haemoglobinopathy, as some patients with thalassaemia are also "experts" in producing antibodies)!

I don't believ there is a standard addressing the transfusion of such. They do need to be labeled w the antibody. Considering the sparce amount of plasma in such units I don't see a problem in their routine use except maybe to NICU pts. As long as they are leukos.

When I came to my current hospital they were using expired panel cells. I got rid of the practice because of the QC issue and having to maintain a policy for when to use and not use expired panel cells. I am glad that I did because this issue looks like it is turning into a problem. So as of about 6 months ago, we do not use expired panel cells for any reason. I would rather give antigen negative blood for an antibody I cannot rule out or send the specimen out to the reference lab if we have multiple antibodies that cannot be ruled out. How did the CAP and AABB reps answer this question?

Please check out job listings on the St Charles Health System site: https://nonclinical-stcharleshealthcare.icims.com/jobs/search?ss=1&searchKeyword=scientist We have retirements coming so keep checking for new openings. This is a great place to live and work with choices of working in a small rural hospital or a regional medical center. Room for advancement and a good work culture. Skiing, rock climbing, hiking, mountain biking and boating of many kinds are common activities here. Brew pubs and good restaurants galore. http://www.visitbend.com/ Feel free to message me with questions.