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In my 39+ years (I think David has me by 1 year), I have seen one instance of ABO HDN severe enough to require exchange transfusion with a non-O mom. It was a group A mom and a group B infant and it was at least 30 years ago.

I think I have seen this one time in 40+ yrs. (maybe)

We are a community hospital with a bone marrow/stem cell/cord blood transplant center. Our blood bank medical director is Dr. Joseph Sweeney (you can look up his illustrious credentials). He has recommended that patients receiving fludarabine, bendamustine, claradibine, deoxycoformycin, alemtuzumab, anti-CD52, and campath within 2 years should receive irradiated blood products, but made our policy that they receive irradiated products for life. We usually only deal with fludaribine, but lately bendamustine is being seen a lot. While the transplant team includes blood bank in their weekly meetings, sometimes communicating the meds can be missed. We now have a program in our HIS that when the pharmacy is dispensing these drugs, a printout comes to blood bank so we know and we put an irradiated product marker in our LIS.