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Showing content with the highest reputation on 02/10/2015 in all areas

  1. Was antigen typing done on the patient for K and C at the time the anti-e was identified? When was the patient last transfused? Can you antigen type them now?
    1 point
  2. Personally, I would say no godchild, although I can see your point. I base my answer on a paper/editorial written some years ago by the late, great George Garratty on the subject of whether we should worry about such antibodies when performing electronic issue after a clear antibody screen. I don't have the paper to hand at the moment - they are all at work, but I am at home, and out at a meeting tomorrow, but will post the reference as soon as I can - but he clearly didn't think there was a need. I know there was a paper in Immunohematology not too many years ago about anti-Kpa causing a severe delayed haemolytic transfusion reaction, but, iif you read it closely, the word "severe" was a little bit of an exaggeration!
    1 point
  3. I would give C- e- K- units forever! you don't want this guy making more antibodies
    1 point
  4. Macarton, there are a few of us around. Malcolm, I checked with the boss. As expected there is no education money so I checked with the other boss (wife) and there is no just for fun travel money either. Maybe on your next visit you can get a little closer to my side of the Mississippi. The first pint will be on me.
    1 point
  5. We call it Trace Shite... ETA we are trying to get rid of it
    1 point
  6. Sandy L

    Positive DAT

    You might find this article form John Judd to be of interest: Judd, W.J., et al, The Evaluation of a Positive Direct Antiglobulin Test in Pretransfusion Testing, Transfusion 1980; 20:17-23 In this University of Michigan study, an analysis was performed of 879 samples with positive direct antiglobulin tests. Eluates were performed and 83 were reactive. Most were autoantibodies and a few contained penicillin/Keflin antibodies and a few contained passively acquired anti-A. In only 11 of the 879 cases allo-antibodies were detected in the eluate. After 14 days allo-antibodies detected in the eluate were also detected in the plasma in all but one patient sample that eluted anti-K 17 days post transfusion. The article states, "One of the six patients whose red blood cells eluted a transfusion-induced alloantibody, but in whom the eluted antibody was not detected in the serum by routine pretransfusion screening tests, had been transfused 17 days before a detailed serological evaluation of the DAT was performed (case 4, Table 3). The red blood cells from this patient eluted anti-Kell. This isolated instance does not warrant an extension of our definition of “recently transfused” to a post transfusion interval beyond 14 days, for to do so would only increase the number of samples requiring evaluation with very little corresponding gain in terms of significant serological findings." The University of Michigan established a 14-day cut-off for "recently transfused" when determining if an eluate needs to be performed. We have chosen 28 days as our "recent transfusion" cutoff to perform an eluate. If the DAT becomes positive within 28 days we will perform eluate, if greater than 28 days since transfusion we will not perform eluate. The article was written in 1980 and the automated testing methods for antibody detection widely in use today are likely to be more sensitive than those used in the study.
    1 point
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