More about Hyperhemolytic Syndrome

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Edited June 3, 2015 by RollSlow10

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Edited June 3, 2015 by RollSlow10

[tbostock]

Just curious...is he on antibiotics? Specifically Zosyn (pip tazo)?

[Malcolm Needs ☆]

I just wonder if he has the rarer form of CHAD, where the titre is low, but the thermal range is considerable.  If so, he could be haemolysing the transfused red cells faster than his own red cells, because his own red cells will be covered in C3dg (giving them some form of protection), whilst the transfused red cells will be "virgin" (as far as complement is concerned) and are susceptible to haemolysis by C3d.  It could also be that his DAT is negative with monospecific anti-C3d because of consumption.

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Edited June 3, 2015 by RollSlow10