josieR Posted May 11, 2011 Share Posted May 11, 2011 Can anyone help...?does anyone know the sensitivity and specificity of the Architect CMIA for HTLV I & II??Much appreciated! Link to comment Share on other sites More sharing options...
BrianD Posted May 13, 2012 Share Posted May 13, 2012 Can anyone help...?does anyone know the sensitivity and specificity of the Architect CMIA for HTLV I & II??Much appreciated!hope this helps.b.J Med Virol. 2008 Mar;80(3):484-93.[h=1]Evaluation of a new, fully automated immunoassay for detection of HTLV-I and HTLV-II antibodies.[/h]Qiu X, Hodges S, Lukaszewska T, Hino S, Arai H, Yamaguchi J, Swanson P, Schochetman G, Devare SG.[h=3]Source[/h]Abbott Diagnostics, AIDS Research and Retrovirus Discovery, Abbott Park, Illinois 60064-6015, USA. xiaoxing.qiu@abbott.com[h=3]Abstract[/h]Screening blood donations for human T-lymphotropic virus types I and II (HTLV-I/II) continues to be important in protecting the safety of blood products and controlling the global spread of these retroviruses. We have developed a fully automated, third generation chemiluminescent immunoassay, ARCHITECT rHTLV-I/II, for detection of antibodies to HTLV-I/II. The assay utilizes recombinant proteins and synthetic peptides and is configured in a double antigen sandwich assay format. Specificity of the assay was 99.98% (9,254/9,256, 95% CI = 99.92-100%) with the negative specimens from the general population including blood donors, hospital patients and pregnant women from the US, Japan and Nicaragua. The assay demonstrated 100% sensitivity by detecting 498 specimens from individuals infected with HTLV-I (n = 385) and HTLV-II (n = 113). ARCHITECT rHTLV-I/II results were in complete agreement with the Murex HTLV-I/II reference assay and 99.7% agreement with the Genelabs HTLV Blot 2.4 confirmatory assay. Analytical sensitivity of the assay was equivalent to Murex HTLV-I/II assay based on end point dilutions. Furthermore, using a panel of 397 specimens from Japan, the ARCHITECT rHTLV-I/II assay exhibited distinct discrimination between the antibody negative (Delta Value = -7.6) and positive (Delta Value = 7.6) populations. Based on the excellent specificity and sensitivity, the new ARCHITECT rHTLV-I/II assay should be an effective test for the diagnosis of HTLV-I/II infection and also for blood donor screening Link to comment Share on other sites More sharing options...
TonyDewitt Posted November 16, 2012 Share Posted November 16, 2012 Josie,Were you able to find reliable testing? Link to comment Share on other sites More sharing options...
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