We've had our Echo for coming up on two years. In March of this year, we started seeing a new phenomenon. When we get Rh negative OB patients, very frequently they come up with an Anti-D pattern of at least 2 to 4+. The problem is when we do these manually (tube), they come up negative. If we send them to our reference lab, ALMOST always they come up negative for Anti-D. In ALL cases, these patients have gotten Rhogam. I've tried to find a good way to handle this; we used to do the screen manually and report as negative, but because of those few Antibody ID's that were coming back positive, I felt we were not giving the docs the entire picture. So what we do now is to run the screen on the Echo, if it is positive, we run it manually. If it's negative, we report both workups WITH a comment saying when the patient got Rhogam and that manual testing methods showed no reactivity. It also asks the doctors to notify the lab if they want an ID done. Sometimes they do and sometimes they don't order one; I felt addressing it this way gives the docs all the information they need to make an informed decision about ordering an antibody ID, putting the ball in their court. Since we send these out, it's a significant extra cost for the patient. I have some techs who hate doing it this way (they liked the other way that didn't involve as much work and thought), and some who think it's great; oy vey! But I should mention I'm the only "official" blood banker in my lab as well as being the supervisor; everyone else rotates in and out. Any thoughts, suggestions, anyone else having this problem??