CMS specifies which HCPCS codes allow separate billing for freezing and thawing services. However, it also states that "hospitals may bill the appropriate freezing/thawing CPT code(s) if a frozen/thawed blood product is not transfused, regardless of whether the product's HCPCS code is included in the list...In this scenario, hospitals may not bill the blood product P-code or the transufsion CPT code can be billed. For unused frozen/thawed blood, OPPS providers should bill the appropriate freezing and/or thawing CPT code(s) on the date when the hospital is certain the blood will not be transfused. "
Keep in mind, this terminology is for the Outpatient Setting, since all Inpatient billing is DRG driven. And... I'm a simple blood banker, not a coder/billing specialist.
We usually can reallocate a thawed plasma to another patient within the 24 hour expiration, so have very little waste and do not worry about the above scenario.